London is the capital and largest city of England and the United Kingdom. The city stands on the River Thames in the south-east of England, at the head of its 50-mile (80 km) estuary leading to the North Sea. The City of London, London's ancient core and financial centre − an area of just 1.12 square miles (2.9 km2) and colloquially known as the Square Mile − retains boundaries that closely follow its medieval limits.

San Francisco, officially the City and County of San Francisco, is a cultural, commercial, and financial center of Northern California. San Francisco is the 16th most populous city in the United States, and the fourth most populous in California, with 881,549 residents as of 2019. It covers an area of about 46.89 square miles (121.4 km2), mostly at the north end of the San Francisco Peninsula in the San Francisco Bay Area, making it the second most densely populated large U.S. city, and the fifth most densely populated U.S. county, behind only four of the five New York City boroughs.